Please find below a list of disorders related to the diagnostic category, Substance-Related Disorders. The Substance-Related Disorders Work Group has been responsible for addressing these disorders. Among the work group’s proposals is the recommendation that the diagnostic category include both substance use disorders and non-substance addictions. Gambling disorder has been moved into this category and there are other addiction-like behavioral disorders such as “Internet addiction” that will be considered as potential additions to this category as research data accumulate.  Further, the work group has proposed to tentatively re-title the category, Addiction and Related Disorders. The work group had extensive discussions on the use of the word “addiction.”  There was general agreement that “dependence” as a label for compulsive, out-of-control drug use has been problematic. It has been confusing to physicians and has resulted in patients with normal tolerance and withdrawal being labeled as “addicts.” This has also resulted in patients suffering from severe pain having adequate doses of opioids withheld because of fear of producing “addiction.” Accordingly, the word “dependence” is now limited to physiological dependence, which is a normal response to repeated doses of many medications including beta-blockers, antidepressants, opioids, anti-anxiety agents and other drugs. The presence of tolerance and withdrawal symptoms are not counted as symptoms to be counted for the diagnosis of substance use disorder when occurring in the context of appropriate medical treatment with prescribed medications. Finally, the work group is addressing the disorder pathological gambling, which is currently listed under the diagnostic category Impulse-Control Disorders Not Elsewhere Classified. We appreciate your review and comment on these disorders.